Dapsone: A Century-Old Medicine and a New Hope for Severe COVID-19

Background: The 2020 pandemic of COVID-19 infection, which has already lasted more than 22 months, is not subsiding. Despite the available vaccinations, infection still claiming many lives throughout world, especially among unvaccinated people. newly discovered and fast spreading Omicron variant also raises concern if vaccination alone will be sufficient to win this battle. Purpose: In concept paper, we examine possible use dapsone, a century-old safe medication, treat patients with severe cases pulmonary infection. Methods: We aim delineate similarities between IgA-mediated neutrophil-directed blistering skin diseases by reviewing relevant medical literatures, in order compare pathological mechanisms these two different clinical situations. Results: Analysis published reports reveals strong evidence pointing involvement IgA neutrophils both addition, results small trial showed efficacy dapsone suffered Conclusions: Since effective treating blocking binding tissue site, it could an treatment for lung injury, similar mechanism.